Luiz Belardinelli Selected Research

Flecainide (Tambocor)

1/2022	Open-Label, Multicenter Study of Flecainide Acetate Oral Inhalation Solution for Acute Conversion of Recent-Onset, Symptomatic Atrial Fibrillation to Sinus Rhythm.
1/2020	Multimodal mechanisms and enhanced efficiency of atrial fibrillation cardioversion by pulmonary delivery of a novel flecainide formulation.
1/2019	Optimizing flecainide plasma concentration profile for atrial fibrillation conversion while minimizing adverse ventricular effects by rapid, low-dose intratracheal or intravenous administration.
12/2018	Accelerated conversion of atrial fibrillation to normal sinus rhythm by pulmonary delivery of flecainide acetate in a porcine model.
11/2018	Pulmonary delivery of flecainide causes a rate-dependent predominant effect on atrial compared with ventricular depolarization duration revealed by intracardiac recordings in an intact porcine model.
1/2017	Eleclazine, an inhibitor of the cardiac late sodium current, is superior to flecainide in suppressing catecholamine-induced ventricular tachycardia and T-wave alternans in an intact porcine model.
10/2014	Selective late sodium current blockade with GS-458967 markedly reduces ischemia-induced atrial and ventricular repolarization alternans and ECG heterogeneity.

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Luiz Belardinelli Research Topics

Disease

39	Atrial Fibrillation 01/2022 - 01/2004
24	Ischemia 10/2016 - 07/2006
20	Ventricular Tachycardia 01/2020 - 09/2003
19	Heart Failure 01/2018 - 05/2006
17	Torsades de Pointes (Torsade de Pointes) 01/2018 - 08/2003
12	Cardiac Arrhythmias (Arrythmia) 01/2019 - 10/2007
11	Ventricular Fibrillation 01/2020 - 10/2008
11	Long QT Syndrome 01/2020 - 08/2003
11	Myocardial Infarction 10/2015 - 10/2007
9	Myocardial Ischemia (Ischemic Heart Diseases) 01/2016 - 06/2008
9	Type 2 Diabetes Mellitus (MODY) 10/2015 - 05/2007
9	Acute Coronary Syndrome 08/2015 - 10/2007
9	Tachycardia (Tachyarrhythmias) 09/2014 - 09/2003
8	Coronary Artery Disease (Coronary Atherosclerosis) 11/2014 - 11/2009
7	Chronic Obstructive Pulmonary Disease (COPD) 12/2013 - 01/2004
6	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/2018 - 02/2013
6	Stable Angina 10/2015 - 05/2013
6	Asthma (Bronchial Asthma) 03/2007 - 01/2004
5	Channelopathies 01/2018 - 08/2004
5	Hypoxia (Hypoxemia) 01/2017 - 01/2005
5	Hypotension (Low Blood Pressure) 12/2015 - 09/2003
4	Bradycardia 01/2022 - 04/2003
4	Fibrosis (Cirrhosis) 01/2017 - 08/2006
4	Diastolic Heart Failure 01/2016 - 07/2011
4	Heart Diseases (Heart Disease) 03/2015 - 08/2011
4	Left Ventricular Dysfunction 01/2014 - 12/2006
4	Hyperemia 12/2012 - 01/2003
4	Contracture 05/2011 - 05/2006
4	Lung Diseases (Lung Disease) 02/2010 - 01/2005
4	Insulin Resistance 01/2009 - 04/2007
3	Atrial Flutter (Flutter, Atrial) 01/2022 - 03/2002
3	Atrial Remodeling 01/2021 - 03/2002
3	Atrioventricular Block 01/2018 - 05/2006
3	Hypertrophy 01/2018 - 08/2013
3	Premature Cardiac Complexes (Extrasystoles) 01/2017 - 10/2008
3	Pulmonary Hypertension 06/2015 - 06/2012
3	Hyperglycemia 10/2014 - 06/2010
3	Coronary Stenosis (Coronary Artery Stenosis) 10/2014 - 04/2011
3	Cardiac Sudden Death (Sudden Cardiac Arrest) 07/2014 - 08/2010
3	Pathologic Constriction (Stenosis) 01/2013 - 10/2009
2	Pain (Aches) 01/2022 - 11/2008
2	Ventricular Premature Complexes (Premature Ventricular Contraction) 01/2021 - 01/2018
2	Long Qt Syndrome 3 01/2020 - 11/2016
2	Long QT syndrome type 3 01/2018 - 01/2018
2	Infarction (Infarctions) 01/2014 - 09/2012
2	Dyslipidemias (Dyslipidemia) 04/2013 - 01/2009
2	Inflammation (Inflammations) 12/2012 - 03/2007
2	Pulmonary Fibrosis (Fibrosing Alveolitis) 06/2012 - 01/2005
1	Cough 01/2022

Drug/Important Bio-Agent (IBA)

74	Ranolazine FDA Link 01/2021 - 08/2004
42	SodiumIBA 01/2020 - 08/2004
17	Pharmaceutical PreparationsIBA 01/2020 - 12/2003
14	Sodium Channels (Sodium Channel)IBA 01/2017 - 12/2006
13	Adenosine (Adenocard)FDA LinkGeneric 01/2014 - 09/2003
10	6- (4- (trifluoromethoxy)phenyl)- 3- (trifluoromethyl)(1,2,4)triazolo(4,3- a)pyridineIBA 01/2020 - 01/2013
10	Purinergic P1 Receptors (Adenosine Receptor)IBA 01/2014 - 01/2005
8	CalciumIBA 01/2018 - 07/2006
7	Flecainide (Tambocor)FDA LinkGeneric 01/2022 - 10/2014
7	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 01/2019 - 09/2011
7	Neurofibromin 2 (Merlin)IBA 08/2015 - 10/2007
7	regadenoson FDA Link 02/2012 - 01/2003
6	Anti-Arrhythmia AgentsIBA 01/2021 - 03/2008
6	eleclazineIBA 01/2018 - 01/2016
6	Dronedarone FDA Link 01/2016 - 09/2010
6	Glucose (Dextrose)FDA LinkGeneric 10/2015 - 05/2007
5	E 4031IBA 01/2020 - 09/2009
5	3- ethyl- 1- propyl- 8- (1- (3- trifluoromethylbenzyl)- 1H- pyrazol- 4- yl)- 3,7- dihydropurine- 2,6- dioneIBA 01/2014 - 08/2006
5	Nonesterified Fatty Acids (NEFA)IBA 04/2013 - 04/2003
4	Metoprolol (Toprol-XL)FDA LinkGeneric 01/2020 - 02/2006
4	Amiodarone (Amiodarona)FDA LinkGeneric 03/2017 - 02/2008
4	Epinephrine (Adrenaline)FDA LinkGeneric 01/2017 - 12/2015
4	2- (6- ((2- hydroxycyclopentyl)amino)purin- 9- yl)- 5- ((2- fluorophenylthio)methyl)oxolane- 3,4- diolIBA 04/2013 - 05/2006
4	Fatty Acids (Saturated Fatty Acids)IBA 01/2009 - 02/2007
3	Adrenergic Agents (Adrenergic Drugs)IBA 01/2019 - 12/2015
3	CatecholaminesIBA 01/2018 - 12/2015
3	Proteins (Proteins, Gene)FDA Link 01/2017 - 01/2014
3	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2016 - 07/2006
3	Acetylcholine (Acetylcholine Chloride)FDA Link 04/2016 - 07/2009
3	Nitroglycerin (Dynamite)FDA LinkGeneric 11/2014 - 05/2013
3	beta-apocarotenoid-14',13'-dioxygenase (ADO)IBA 12/2012 - 09/2003
3	Vasodilator Agents (Vasodilators)IBA 02/2012 - 10/2009
3	Tetrodotoxin (Tetradotoxin)IBA 04/2011 - 11/2008
3	para- trifluoro- methyl- 5- phenyl- 1,2,4- oxadiazoleIBA 04/2008 - 02/2007
3	tecadenosonIBA 06/2005 - 04/2003
2	toxin II (Anemonia sulcata)IBA 01/2020 - 08/2004
2	ChloraloseIBA 04/2016 - 01/2016
2	IvabradineIBA 03/2015 - 12/2014
2	Enalapril FDA LinkGeneric 01/2014 - 11/2008
2	Bleomycin (Blenoxane)FDA LinkGeneric 06/2012 - 08/2006
2	Sotalol (Sotalol Hydrochloride)FDA LinkGeneric 04/2011 - 08/2004
2	Interleukin-6 (Interleukin 6)IBA 02/2010 - 01/2005
2	Purinergic P1 Receptor AgonistsIBA 02/2006 - 01/2004
2	Interleukin-11 (Interleukin 11)IBA 03/2002 - 03/2002

Therapy/Procedure

13	Therapeutics 01/2017 - 03/2002
4	Electrodes (Electrode) 10/2014 - 08/2004
3	Electric Countershock (Cardioversion) 01/2022 - 01/2020
3	Drug Therapy (Chemotherapy) 04/2018 - 01/2004
2	Glycemic Control 07/2015 - 10/2014
2	Catheters 10/2014 - 01/2013
2	Induced Heart Arrest (Cardioplegia) 09/2009 - 06/2009